Product Datasheet
LMNB2 Antibody
Catalog Number: 48494
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#:Q03252
- Form of Antibody:
- 1*TBS (pH7.4), 0.5%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
- appl_detail:
- WB: 1:1,000-1:2,000
IHC: 1:200
ICC: 1:200
- other_names:
- LAMB 2 antibody LAMB2 antibody Lamin-B2 antibody LMN 2 antibody LMN B2 antibody LMN2 antibody LMNB 2 antibody LMNB2 antibody LMNB2_HUMAN antibody MGC2721 antibody RGD1563803 antibody
- Purification:
- Peptide affinity purified
- Applications:
- WB, ICC, IHC
- Background:
- Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations. Defects in LMNB2 are a cause of partial acquired lipodystrophy (APLD), which is a rare childhood disease characterized by loss of subcutaneous fat from the face and trunk.
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