Product Datasheet  
YAP65 Antibody  
Catalog Number: 48351  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P46937
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Amino acids 206-330 mapping near the C-terminus of YAP of human origin.
  • reactivity：  
  • Hu, Ms, Rt
  • appl_detail：  
  • WB: 1:100-1:1,000
    IHC: 1:50-1:500

    IP: 1-2 μg per 100-500 μg of total protein (1 ml of cell lysate)
  • other_names：  
  • 65 kDa Yes associated protein antibody
    65 kDa Yes-associated protein antibody
    COB1 antibody
    YAp 1 antibody
    YAP 65 antibody
    YAP antibody
    YAP1 antibody
    YAP1_HUMAN antibody
    YAP2 antibody
    YAP65 antibody
    yes -a
  • Purification：  
  • Immunogen affinity purified
  • Specificity：  
  • Applications：  
  • WB, IP, IF, IHC(P)
  • Background：  
  • The Yes-associated protein, otherwise known as YAP, is a 14-3-3-binding molecule that was originally recognized by virtue of its ability to bind to the SH3 domain of Yes. The binding of YAP to 14-3-3 requires the phosphorylation of a homologous serine residue (Ser 112) in the YAP 14-3-3-binding motif. The highly conserved and ubiquitously expressed 14-3-3 proteins regulate differentiation, cell cycle progression and apoptosis by binding intracellular phosphoproteins involved in signal transduction. YAP may link events at the plasma membrane and cytoskeleton to inhibition of transcription in the nucleus in a manner regulated by 14-3-3 proteins. YAP shares homology with the WW domain of TAZ, transcriptional co-activator with PDZ-binding motif, which functions as a transcriptional co-activator by binding to the PPXY motif present in transcription factors. YAP is expressed at high levels in the lung, placenta, prostate, ovary and testis.



 
© Signalway Biotechnology All Rights Reserved.