Product Datasheet  
MAdCAM-1 Antibody  
Catalog Number: 48313  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q13477
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Endothelial cells from BALB/c mouse mesenteric and peripheral lymph nodes.
  • reactivity：  
  • Hu, Ms, Rt
  • appl_detail：  
  • WB: 1:100-1:1,000


    IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
    FC: 1 μg per 1 x 106 cells
  • other_names：  
  • Addressin mucosal antibody
    hMAdCAM 1 antibody
    hMAdCAM-1 antibody
    MACAM1 antibody
    MADCA_HUMAN antibody
    MAdCAM 1 antibody
    MAdCAM-1 antibody
    Madcam1 antibody
    Mucosal addressin cell adhesion molecule 1 antibody
    Muc
  • Purification：  
  • Immunogen affinity purified
  • Specificity：  
  • Applications：  
  • WB, IP, IF, FCM
  • Background：  
  • The recirculation of lymphocytes through different organs is thought to be regulated by adhesion molecules (homing receptors) recognizing tissue-specific vascular addressins on the endothelium. The mucosal vascular addressin, MadCAM-1 (mucosal addressin cell adhesion molecule 1), is an immunoglobulin superfamily adhesion molecule for lymphocytes that is expressed by mucosal venules and helps direct lymphocyte traffic into Peyers patches and the intestinal lamina propria. MadCAM-1 acts as an endothelial cell ligand for leukocyte homing receptors L-Selectin and Integrin α4/β7. MadCAM-1 is strongly expressed on inflamed portal vein/sinusoidal endothelium in autoimmune-mediated liver disease and plays a major contributory role in the progression of chronic experimental autoimmune encephalomyelitis.



 
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