Product Datasheet  
IRS-2 Antibody  
Catalog Number: 48310  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q9Y4H2
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Amino acids 926-1130 of IRS-2 of human origin.
  • reactivity：  
  • Hu, Ms, Rt
  • appl_detail：  
  • WB: 1:100-1:1,000


    IP: 1-2 μg per 100-500 μg of total protein (1 ml of cell lysate)
  • other_names：  
  • Insulin receptor substrate 2 antibody
    IRS 2 antibody
    IRS-2 antibody
    Irs2 antibody
    IRS2_HUMAN antibody
  • Purification：  
  • Immunogen affinity purified
  • Specificity：  
  • Applications：  
  • WB, IP, IF
  • Background：  
  • IRS-2, originally described as 4PS, acts as a signaling intermediate downstream of the Insulin, IGF-1, IL-4, IL-9 and IL-13 receptors. In IRS-2-deficient mice, reduction in total PI 3-kinase activity by 30% and abolition of downstream activation of protein kinase C (PKC) ζ leads to the development of type 2 diabetes. Additionally, reconstitution with retroviral IRS-2 restores IRS-2/PI 3-kinase/PKC ζ signalling as well as glucose uptake. IRS-2 translocates to the nuclei of mouse embryo fibroblasts expressing the Insulin-like growth factor 1 receptor. Various mutations in the IGF-IR can result in an abrogation of or decrease in the translocation of IRS proteins to the nucleoli. IRS-2 is responsible for mitogen-activated protein kinase (MAPK) and protein kinase B (PKB) activation by Insulin and is the major adapter molecule linking the Insulin receptor to this step.



 
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