Product Datasheet  
NF-κB p105/p50 Antibody  
Catalog Number: 48268  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P19838
  • Form of Antibody：  
  • 1*TBS (pH7.4), 0.5%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • A synthetic peptide corresponding to residues in the nuclear factor NF-κB p50 subunit.
  • reactivity：  
  • Hu, Ms, Rt
  • appl_detail：  
  • WB: 1:1,000
    IHC: 1:250-1:500
    ICC: 1:250-1:500
    IP: 1:30
  • other_names：  
  • DKFZp686C01211 antibody
    DNA binding factor KBF1 antibody
    DNA binding factor KBF1 EBP1 antibody
    DNA-binding factor KBF1 antibody
    EBP 1 antibody
    EBP-1 antibody
    EBP1 antibody
    KBF1 antibody
    MGC54151 anti
  • Purification：  
  • Protein A purified
  • Specificity：  
  • Applications：  
  • WB, ICC, IHC, FC, IP
  • Background：  
  • Nuclear factor κB (NF-κB) encompasses an important family of inducible transcriptional activators that regulate a wide variety of cellular and viral genes. The family members include p50, p52, p65 (RelA), c-Rel, and RelB. Association with inhibitory proteins of the IκB family retains NF-κB in the cytoplasm. Degradation of IκB proteins exposes the nuclear localization sequence (NLS), leading to nuclear translocation and subsequent binding of NF-B to DNA. The p105 precursor protein acts as an NFκB inhibitor, retaining Rel subunits in the cytoplasm of unstimulated cells. Upon stimulation by TNFα and IL -1α, degradation of p105 occurs; the Rel subunit is released and translocats to the nucleus. Additionally, p105 will be proteolytically processed by the 26S proteasome to produce a smaller, transcriptionally active form (p50).



 
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