Product Datasheet  
Pygopus 2 Antibody  
Catalog Number: 48229  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q9BRQ0
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • peptide
  • reactivity：  
  • Hu, Ms
  • appl_detail：  
  • WB: 1:1,000



    FC: 1:50-1:100
  • other_names：  
  • 1190004M21Rik antibody
    FLJ33226 antibody
    PP7910 antibody
    PYGO2 antibody
    Pygo2 protein antibody
    PYGO2_HUMAN antibody
    Pygopus 2 antibody
    pygopus homolog 2 (Drosophila) antibody
    Pygopus homolog 2 antibody
  • Purification：  
  • Peptide affinity purified
  • Specificity：  
  • Applications：  
  • WB, FC
  • Background：  
  • Pygopus 2, also known as PYGO2, is a 406 amino acid protein that is the human homolog of the Drosophila pygopus protein. Localized to the nucleus, Pygopus 2 contains one PHD finger that interacts with the homology domain of the Wnt signaling protein Bcl-9. This interaction joins Pygopus 2 with the -catenin/TCF complex (a crucial complex in Wnt signaling), thereby allowing -catenin to transcriptionally activate Wnt target genes. Association of Pygopus 2 with proteins involved in the Wnt signaling pathway is thought to regulate proper signal transduction, as absence of the Pygopus 2/-catenin interaction may play a role in development of B-cell malignancies. In addition, Pygopus 2 expression is upregulated in and required for the growth of breast cancer cells, suggesting a crucial role in carcinogenesis.



 
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