Product Datasheet  
Nrf2 Antibody  
Catalog Number: 48185  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q16236
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to Nrf2 aa 530-600.
  • reactivity：  
  • Hu, Ms, Rt
  • appl_detail：  
  • WB: 1:1000-1:2,000

    ICC: 1:100

  • other_names：  
  • erythroid derived 2 antibody
    HEBP1 antibody
    like 2 antibody
    NF E2 related factor 2 antibody
    NF-E2-related factor 2 antibody
    NF2L2_HUMAN antibody
    NFE2 related factor 2 antibody
    NFE2-related factor 2 antibody
  • Purification：  
  • Peptide affinity purified
  • Specificity：  
  • Applications：  
  • WB, ICC
  • Background：  
  • The Nrf2 antioxidant response pathway is "the primary cellular defense against the cytotoxic effects of oxidative stress." Among other effects, NFE2L2 increases the expression of several antioxidant enzymes. Several drugs that stimulate the NFE2L2 pathway are being studied for treatment of diseases that are caused by oxidative stress, and dimethyl fumarate significantly reduced the progression of disability in multiple sclerosis. Under normal or unstressed conditions, Nrf2 is kept in the cytoplasm by a cluster of proteins that degrade it quickly. Under oxidative stress, Nrf2 is not degraded, but instead travels to the nucleus where it binds to a DNA promoter and initiates transcription of antioxidative genes and their proteins.



 
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