Product Datasheet  
APAF1 Antibody  
Catalog Number: 48182  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:O14727
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • peptide
  • reactivity：  
  • Hu,Ms
  • appl_detail：  
  • WB: 1:500-1:1000



  • other_names：  
  • APAF 1 antibody
    Apaf-1 antibody
    APAF_HUMAN antibody
    Apaf1 antibody
    Apoptotic peptidase activating factor 1 antibody
    Apoptotic protease activating factor 1 antibody
    Apoptotic protease activating factor antibody
    Apoptotic
  • Purification：  
  • Peptide affinity purified
  • Specificity：  
  • Applications：  
  • WB
  • Background：  
  • Apoptotic protease activating factor 1, also known as APAF1, is a human homolog of C. elegans CED-4 gene. This gene encodes a cytoplasmic protein that forms one of the central hubs in the apoptosis regulatory network. This protein contains (from the N terminal) a caspase recruitment domain (CARD), an ATPase domain (NB-ARC), few short helical domains and then several copies of the WD40 repeat domain. Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. The precise mechanism for this reaction is still debated though work published by Guy Salvesen suggests that the apoptosome may induce caspase 9 dimerization and subsequent autocatalysis. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis.



 
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