Product Datasheet  
TOP2A Antibody  
Catalog Number: 48172  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q01320
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • recombinant protein
  • reactivity：  
  • Hu,Ms,Rt
  • appl_detail：  
  • WB: 1:1,000-1:2,000

    ICC: 1:200

  • other_names：  
  • alpha isozyme antibody
    ATP hydrolyzing DNA topoisomerase II alfa antibody
    DNA gyrase antibody
    DNA topoisomerase (ATP hydrolyzing) antibody
    DNA topoisomerase 2 alpha antibody
    DNA topoisomerase 2-alpha antibody
    DNA topoisomeras
  • Purification：  
  • Immunogen affinity purified
  • Specificity：  
  • Applications：  
  • WB, ICC
  • Background：  
  • DNA topoisomerases I and II are nuclear enzymes; type II consists of two highly homologous isoforms: topoisomerase IIα and IIβ. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Topoisomerases are very susceptible to various stresses. Acidic pH or oxidative stress can convert topoisomerases to DNA-breaking nucleases, causing genomic instability and cell death. DNA-damaging topoisomerase targeting drugs (e.g., etoposide) also convert topoisomerases to nucleases, with the enzyme usually trapped as an intermediate that is covalently bound to the 5+ end of the cleaved DNA strand(s).



 
© Signalway Biotechnology All Rights Reserved.