Product Datasheet  
NF-κB p105/p50 Antibody  
Catalog Number: 48171  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P19838
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to residues in the nuclear factor NF-κB p50 subunit.
  • reactivity：  
  • Hu,Ms
  • appl_detail：  
  • WB: 1:500-1:1,000
    IHC: 1:200
    ICC: 1:200-1:500

  • other_names：  
  • DKFZp686C01211 antibody
    DNA binding factor KBF1 antibody
    DNA binding factor KBF1 EBP1 antibody
    DNA-binding factor KBF1 antibody
    EBP 1 antibody
    EBP-1 antibody
    EBP1 antibody
    KBF1 antibody
    MGC54151 anti
  • Purification：  
  • Immunogen affinity purified
  • Specificity：  
  • Applications：  
  • WB, ICC, IHC
  • Background：  
  • NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators.



 
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