Product Datasheet  
Caspase-9 Antibody  
Catalog Number: 48161  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P55211
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • peptide
  • reactivity：  
  • Hu
  • appl_detail：  
  • WB: 1:1,000-1:2,000
    IHC: 1:200


  • other_names：  
  • APAF-3 antibody
    APAF3 antibody
    Apoptosis related cysteine peptidase antibody
    Apoptotic protease Mch-6 antibody
    Apoptotic protease-activating factor 3 antibody
    CASP-9 antibody
    CASP9 antibody
    CASP9_HUMAN antibody
    Casp
  • Purification：  
  • Immunogen affinity purified
  • Specificity：  
  • Applications：  
  • WB, IHC
  • Background：  
  • Caspase-9 (ICE-LAP6, Mch6) is an important member of the cysteine aspartic acid protease (caspase) family. It is known to be involved in the activation cascade of caspases responsible for apoptosis execution. Upon apoptotic stimulation, cytochrome c released from mitochondria associates with the 47 kDa procaspase-9/Apaf 1. Apaf-1 mediated activation of caspase-9 involves instrinsic proteolytic processing resulting in cleavage at Asp315 and producing a p35 subunit. Another cleavage occurs at Asp330 producing a p37 subunit that can serve to amplify the apoptotic response. Cleaved caspase-9 further processes other caspase members, including caspase-3 and caspase-7, to initiate a caspase cascade, which leads to apoptosis.



 
© Signalway Biotechnology All Rights Reserved.