Product Datasheet  
Autoimmune regulator (AIRE) Antibody  
Catalog Number: 48149  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:O43918
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • This antibody is produced by immunizing rabbits with full length recombinant protein of mouse AIRE.
  • reactivity：  
  • Hu,Ms
  • appl_detail：  
  • WB: 1:2,000



  • other_names：  
  • AIRE antibody
    AIRE_HUMAN antibody
    AIRE1 antibody
    APECED antibody
    APECED protein antibody
    APS1 antibody
    APSI antibody
    Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein antibody
    Au
  • Purification：  
  • Immunogen affinity purified
  • Specificity：  
  • Applications：  
  • WB
  • Background：  
  • The Autoimmune Regulator (AIRE) is a human transcription factor expressed at higher level in thymus, pancreas, adrenal cortex, and testis. It is expressed at lower level in the spleen, fetal liver and lymph nodes. It contains zinc finger motifs and isoform 1 is localized to both the nucleus and cytoplasm. Three splice variant mRNAs products have been described. In the thymus it causes transcription of a wide selection of organ-specific genes which create proteins that are usually only expressed in peripheral tissues, creating an "immunological self-shadow" in the thymus. Defects in AIRE are a cause of autoimmune poly-endocrinopathy candidiasis ectodermal dystrophy (APECED), also known as autoimmune polyglandular syndrome type I (APS-1).



 
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