Product Datasheet
UTF1 Antibody
Catalog Number: 48148
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#:Q5T230
- Form of Antibody:
- 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
- appl_detail:
- WB: 1:1,000-1:2,000
IHC: 1:200
- other_names:
- hUTF 1 antibody hUTF1 antibody Undifferentiated embryonic cell transcription factor 1 antibody UTF 1 antibody UTF1 antibody UTF1_HUMAN antibody
- Purification:
- Immunogen affinity purified
- Background:
- Undifferentiated embryonic cell transcription factor 1 (UTF1) is expressed in cells of the inner cell mass and the epiblast. Upon activation by Oct-3/4, UTF1 may be responsible for the rapid proliferation and tumorigenic properties of embryonic stem cells. Sox2 is also part of the Oct-3/4-containing complex able to bind the regulatory region of UTF1. UTF1 acts as a transcriptional coactivator of ATF2 and it binds to the N-terminal region of ATF2. Reduced expression in embryonic stem cells (ESCs) is associated with failure to differentiate properly, although self-renewal is unaffected.
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