Product Datasheet  
CD73 Antibody  
Catalog Number: 48131  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P21589
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to a region of human CD73 (aa 240-270).
  • reactivity：  
  • Hu, Ms
  • appl_detail：  
  • WB: 1:1,000-1:2,000

    ICC: 1:50-1:200

    FC: 1:50-1:100
  • other_names：  
  • 5' NT antibody
    5' nucleotidase (CD73) antibody
    5' nucleotidase precursor antibody
    5' nucleotidase, ecto antibody
    5' nucleotidase, ecto (CD73) antibody
    5'-NT antibody
    5'-nucleotidase antibody
    5NTD_HUMAN anti
  • Purification：  
  • Peptide affinity purified.
  • Specificity：  
  • Applications：  
  • WB, ICC, FC
  • Background：  
  • CD73 (also designated ecto-5'-nucleotidase, E5NT, NT, NT5, NTE, eN and eNT) is a glycosyl-phosphatidylinositol (GPI)-anchored adhesion protein that catalyzes the dephosphorylation of extracellular purine and pyrimidine nucleotides to their corresponding bioactive nucleosides. CD73 is a dimer of two identical subunits that depends on GPI to link with the external face of the plasma membrane. Similar to other GPI-anchored proteins, CD73 mediates co-stimulatory signals in T cell activation. CD73 has few structural variants, yet elicits diverse biological function through differential regulation in endothelial cells (EC), subpopulations of B and T cells, germinal center follicular dendritic cells and on thymic medullary reticular fibroblasts. For example, IgG mediated neutralization of CD73 interferes with lymphocyte adhesion to EC, and blocks aggregation of germinal center B cells and follicular dendritic cells. Furthermore, IgG-mediated targeting of lymphocyte CD73, but not of endothelial cell CD73, causes shedding of CD73 and tyrosine phosphorylation of proteins.



 
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