Product Datasheet  
Netrin receptor DCC Antibody  
Catalog Number: 48042  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P43146
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • recombinant protein
  • reactivity：  
  • Hu,Ms
  • appl_detail：  
  • WB: 1:500-1:1,000



  • other_names：  
  • Colorectal cancer related chromosome sequence 18 antibody
    Colorectal cancer suppressor antibody
    CRC 18 antibody
    CRC18 antibody
    CRCR 1 antibody
    CRCR1 antibody
    DCC antibody
    DCC_HUMAN antibody
    Deleted in colorectal can
  • Purification：  
  • Immunogen affinity purified
  • Specificity：  
  • Applications：  
  • WB, ICC, IHC, FC
  • Background：  
  • Netrin receptor DCC (deleted colorectal careinoma) was originally identified as a putative tumor suppressor gene that is lost in more than 70% of colorectal cancers. The DCC protein is a type I transmembrane glycoprotein that belongs to the immunoglobulin (Ig) superfamily. It is found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Native DCC is found in three isoforms. Two forms, a long and a short isoform, are produced from the same gene but have different initiation sites. The third isoform, produced by alternative splicing, is expressed only in embryonic tissue. Colorectal tumors that lost their capacity to differentiate into mucus producing cells uniformly lack DCC expression. Inactivation of DCC due to allelic deletion or point mutations may cause both lymphatic and hematogenous metastasis of esophageal squamous cell carcinomas.



 
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