Product Datasheet  
PDGF Receptor beta(Phospho- Y740) Antibody  
Catalog Number: 13396  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:P05622
  • Form of Antibody：  
  • 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthetic phospho-peptide corresponding to residues surrounding Tyr740 of human PDGF Receptor beta.
  • reactivity：  
  • Ms, Rt
  • appl_detail：  
  • WB: 1:1,000

    ICC: 1:50-1:200

  • other_names：  
  • Beta platelet derived growth factor receptor antibody
    Beta-type platelet-derived growth factor receptor antibody
    CD 140B antibody
    CD140 antigen-like family member B antibody
    CD140b antibody
    CD140b antigen antibody
  • Purification：  
  • ProA affinity purified
  • Specificity：  
  • Applications：  
  • WB, ICC/IF
  • Background：  
  • Platelet Derived Growth Factor (PDGF) is a mitogen for mesenchyme- and glia-derived cells. PDGF consists of two chains, A and B, which dimerize to form functionally distinct isoforms, PDGF-AA, PDGF-AB, and PDGF-BB. These three isoforms bind with different affinities to two receptor types, a and b, which are endowed with protein tyrosine kinase domains and undergo either homo- or heterodimerization as a consequence of ligand binding. Ligand stimulation of PDGFR-b leads to autophosphorylation at Tyr-857, which is the major autophosphorylation site, and Tyr-751, which is the major in vitro phosphorylation site. Autophosphorylation of Tyr-751, which lies in the kinase insert region, is required for binding of phosphatidylinositol-3 kinase to the receptor. These auto-phosphorylation events largely contribute to signal transduction through the PDGF receptor.



 
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