Product Datasheet
IKB alpha(Phospho-S32) Antibody
Catalog Number: 13376
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#:P25963
- Form of Antibody:
- 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
- Immunogen:
- Synthetic phospho-peptide corresponding to residues surrounding Ser32 of human IKB alpha.
- appl_detail:
- WB: 1:1,000
ICC: 1:50-1:200
- other_names:
- I kappa B alpha antibody
I-kappa-B-alpha antibody
IkappaBalpha antibody
IkB-alpha antibody
IKBA antibody
IKBA_HUMAN antibody
IKBalpha antibody
MAD 3 antibody
MAD3 antibody
Major histocompatibi
- Purification:
- ProA affinity purified
- Applications:
- WB, ICC, IP
- Background:
- On the basis of both functional and structural considerations, members of the IκB family of proteins can be divided into four groups. The first of these groups, IκB-α, includes the avian protein pp40 and the mammalian MAD-3, both of which inhibit binding of p50-p65 NFkB complex or Rel protein to their cognate binding sites but do not inhibit the binding of p50 homodimer to κB sites, suggesting that the IκB-α family binds to the p65 subunit of p50-p65 heterocomplex through ankyrin repeats. The second member of the IκB family is represented by a protein designated IκB-β. The third group of IκB proteins is represented by IκB-γ, which is identical in sequence with the C-terminal domain of the p110 precursor of NFkB p50 and is expressed predominantly in lymphoid cells. An additional IκB family member, IκB-ε, has several phosphorylated forms and is primarily found complexed with Rel A and/or c-Rel.
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