Product Datasheet
SGCG Antibody
Catalog Number: 47203
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#:Q13326
NCBI Gene ID:6445
Gene Accssion:NP_000222
- Form of Antibody:
- Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
- Immunogen:
- Synthetic peptide of human SGCG
- appl_detail:
Immunofluorescence:1: 20-100
- other_names:
- A4; MAM; DMDA; SCG3; 35DAG; DAGA4; DMDA1; LGMD2C; SCARMD2; gamma-SG
- Purification:
- Antigen affinity purification
- Specificity:
- The antibody detects endogenous levels of total SGCG protein.
- Background:
- This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C).?
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