Product Datasheet
MYCN Antibody
Catalog Number: 46618
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot:P04198
NCBI Gene ID:4613
NCBI Protein:NP_005369
- Form of Antibody:
- Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
- Immunogen:
- Synthetic peptide corresponding to internal residues of human MYCN
- appl_detail:
- Western blotting: 1:200-1:1000
- other_names:
- NMYC; ODED; MODED; N-myc; bHLHe37
- Purification:
- Antigen affinity purification
- Specificity:
- The antibody detects endogenous levels of total MYCN protein.
- Background:
- This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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