Product Datasheet
DNAJC2 Antibody
Catalog Number: 46553
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot:Q99543
NCBI Gene ID:27000
NCBI Protein:NP_055192
- Form of Antibody:
- Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
- Immunogen:
- Synthetic peptide corresponding to residues near the C terminal of human DNAJC2
- appl_detail:
Immunohistochemistry: 1: 30-150
- other_names:
- ZRF1; ZUO1; MPP11; MPHOSPH11
- Purification:
- Antigen affinity purification
- Specificity:
- The antibody detects endogenous levels of total DNAJC2 protein.
- Background:
- This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described.?
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