Product Datasheet  
CD276 Antibody  
Catalog Number: 46434  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q5ZPR3
    NCBI Gene ID:80381
    NCBI Protein:NP_001019907
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthetic peptide corresponding to residues near the C terminal of human CD276
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:200-1:1000
    Immunohistochemistry: 1: 25-100
  • other_names：  
  • B7H3; B7-H3; B7RP-2; 4Ig-B7-H3
  • Purification：  
  • Antigen affinity purification
  • Specificity：  
  • The antibody detects endogenous levels of total CD276 protein.
  • Applications：  
  • WB IHC
  • Background：  
  • The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.



 
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