Product Datasheet  
DTX3L Antibody  
Catalog Number: 43874  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: Q8TDB6
    NCBI Gene ID: 151636
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Fusion protein of human DTX3L
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:200-1000
  • other_names：  
  • BBAP
  • Purification：  
  • Antigen affinity purification
  • Specificity：  
  • The antibody detects endogenous levels of total DTX3L protein.
  • Applications：  
  • WB
  • Background：  
  • The Deltex family is responsible for influencing Notch signaling and may regulate transcription through interactions with specific transcription factors. Deltex proteins have a basic N-terminus, a central proline-rich region and a C-terminal RING-type zinc finger domain, a motif often found in ubiquitin-protein isopeptide ligases (E3). The RING-type zinc finger domain binds two Zn2+ atoms and forms a cross-brace motif that is essential for many proteins involved the ubiquitination pathway. DTX3L (Deltex-3-like), also known as BBAP, is a 740 amino acid protein that is similar to Deltex-3 and acts as a ubiquitin ligase in vitro. DTX3L can heterodimerize with Deltex-1, a transcriptional regulator, thereby enhancing the activity of the E3 ubiquitin ligase complex and increasing the influence of E3 on the Notch signaling pathway.



 
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