Product Datasheet
NANOS1 Antibody
Catalog Number: 43311
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#: Q8WY41
Gene ID: 340719
- Form of Antibody:
- Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
- Immunogen:
- Synthetic peptide of human NANOS1
- appl_detail:
- Western blotting: 1:500-1:2000
Immunohistochemistry: 1:10-1:50
- other_names:
- NOS1; SPGF12
- Purification:
- Antigen affinity purification.
- Specificity:
- The antibody detects endogenous levels of total NANOS1 protein.
- Background:
- Nanos1, also known as NOS1, is a 292 amino acid protein that localizes to the perinuclear region of the cytoplasm and contains one nanos-type zinc finger. Expressed at high levels in spermatogonia and present at lower levels in fetal ovaries, Nanos1 forms a complex with Pumilio 2 and functions to regulate the translation of select mRNAs, specifically via association with the 3¡¯-UTR of its mRNA targets. Additionally, Nanos1 is required for the establishment and maintenance of germline stem cells, as it prevents their premature entry into oogenesis.
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