Product Datasheet
ENPP1 Antibody
Catalog Number: 43266
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#: P22413
Gene ID: 5167
- Form of Antibody:
- Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
- Immunogen:
- Synthetic peptide of human ENPP1
- appl_detail:
Immunohistochemistry: 1:20-1:100
- other_names:
- M6S1; NPP1; NPPS; PC-1; PCA1; ARHR2; COLED; PDNP1
- Purification:
- Antigen affinity purification.
- Specificity:
- The antibody detects endogenous levels of total ENPP1 protein.
- Background:
- This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance.
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