Product Datasheet
COL15A1 Antibody
Catalog Number: 43264
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#: P39059
Gene ID: 1306
- Form of Antibody:
- Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
- Immunogen:
- Synthetic peptide of human COL15A1
- appl_detail:
Immunohistochemistry: 1:10-1:50
- other_names:
- COFA1; COL15A1; Collagen alpha-1(XV) chain; collagen type XV proteoglycan; collagen XV, alpha-1 polypeptide
- Purification:
- Antigen affinity purification.
- Specificity:
- The antibody detects endogenous levels of total COL15A1 protein.
- Background:
- This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. The proteolytically produced C-terminal fragment of type XV collagen is restin, a potentially antiangiogenic protein that is closely related to endostatin. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration.
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