Product Datasheet  
PLEK Antibody  
Catalog Number: 43053  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P08567
    Gene ID: 5341
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Fusion protein of human PLEK
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500-1:2000
    Immunohistochemistry: 1:25-1:100
  • other_names：  
  • P47
  • Purification：  
  • Antigen affinity purification.
  • Specificity：  
  • The antibody detects endogenous levels of total PLEK protein.
  • Applications：  
  • WB IHC
  • Background：  
  • Pleckstrin is highly expressed in human neutrophils. Pleckstrin is rapidly phosphorylated following treatment of neutrophils in response to inflammatory stimuli, probably by nonconventional PKC isoforms delta or zeta, which are expressed in human neutrophils. Phosphorylation by nonconventional PKC isoforms induces a conformational change in pleckstrin that promotes its interaction with membranes and/or with the cytoskeleton, serving to target proteins or lipids recognized by PH domains to sites where they can contribute to the microbicidal response.



 
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