Product Datasheet  
MAPK8IP1 Antibody  
Catalog Number: 37670  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: Q9UQF2
    NCBI Gene ID: 9479
    Gene Accssion: NP_005447
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthetic peptide corresponding to a region derived from internal residues of human mitogen-activated protein kinase 8 interacting protein 1
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Western blotting: 1:200-1:1000
  • other_names：  
  • IB1; JIP1; JIP-1; PRKM8IP
  • Purification：  
  • Antigen affinity purification.
  • Specificity：  
  • The antibody detects endogenous levels of total MAPK8IP1 protein.
  • Applications：  
  • WB
  • Background：  
  • This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.?



 
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