Product Datasheet
SIGLEC6 Antibody
Catalog Number: 37473
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#: O43699
NCBI Gene ID: 946
Gene Accssion: NP_001171018
- Form of Antibody:
- Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
- Immunogen:
- Synthetic peptide corresponding to residues near the C terminal of human sialic acid binding Ig-like lectin 6
- appl_detail:
- Western blotting: 1:500-1:2000
Immunohistochemistry: 1:50-1:200
- other_names:
- CD327; CD33L; OBBP1; CD33L1; CD33L2; CDW327
- Purification:
- Antigen affinity purification.
- Specificity:
- The antibody detects endogenous levels of total SIGLEC6 protein.
- Background:
- The?SIGLEC6?gene to 19q13.3, which is where the CD33 gene is located. Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Expressed at high levels in placenta (cyto- and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine.
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