Product Datasheet  
CCDC88A Antibody  
Catalog Number: 37414  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: Q3V6T2
    NCBI Gene ID: 55704
    Gene Accssion: NP_001129069
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthetic peptide corresponding to a region derived from internal residues of human coiled-coil domain containing 88A
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • Immunohistochemistry: 1:50-1:200
  • other_names：  
  • APE; GIV; GRDN; HkRP1; GIRDIN; KIAA1212
  • Purification：  
  • Antigen affinity purification.
  • Specificity：  
  • The antibody detects endogenous levels of total CCDC88A protein.
  • Applications：  
  • IHC
  • Background：  
  • This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.



 
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