Product Datasheet  
SLC22A17 Antibody  
Catalog Number: 37244  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: Q8WUG5
    NCBI Gene ID: 51310
    Gene Accssion: NP_065105.2
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthetic peptide corresponding to residues near the C terminal of human solute carrier family 22, member 17
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500-1:2000
    Immunohistochemistry: 1:25-1:100
  • other_names：  
  • BOCT; BOIT; 24p3R; NGALR; hBOIT; NGALR2; NGALR3
  • Purification：  
  • Antigen affinity purification.
  • Specificity：  
  • The antibody detects endogenous levels of total SLC22A17 protein.
  • Applications：  
  • WB IHC
  • Background：  
  • Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis.



 
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