Product Datasheet  
PTN Antibody  
Catalog Number: 37225  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P21246
    NCBI Gene ID: 5764
    Gene Accssion: NP_002816
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthetic peptide corresponding to a region derived from internal residues of human pleiotrophin
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Western blotting: 1:500-1:2000
  • other_names：  
  • HARP; HBNF; HBGF8; NEGF1
  • Purification：  
  • Antigen affinity purification.
  • Specificity：  
  • The antibody detects endogenous levels of total PTN protein.
  • Applications：  
  • WB
  • Background：  
  • Pleiotrophin?(PTN) also known as?heparin-binding brain mitogen?(HBBM) or?heparin-binding growth factor 8?(HBGF-8) or?neurite growth-promoting factor 1?(NEGF1) or?heparin affinity regulatory peptide?(HARP) or?heparin binding growth associated molecule?(HB-GAM) is a?protein?that in humans is encoded by the?PTNgene.?Pleiotrophin is an 18-kDa?growth factor?that has a high affinity for?heparin. It is structurally related to?midkine?and?retinoic acid induced heparin-binding protein. Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.



 
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