Product Datasheet
LOXL1 Antibody
Catalog Number: 37706
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#: Q08397
NCBI Gene ID: 4016
Gene Accssion: NP_005567/Q08397
- Form of Antibody:
- Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
- Immunogen:
- Synthetic peptide corresponding to residues near the C terminal of human lysyl oxidase-like 1
- appl_detail:
- Western blotting: 1:200-1:1000
- Purification:
- Antigen affinity purification.
- Specificity:
- The antibody detects endogenous levels of total LOXL1 protein.
- Background:
- This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.?
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