Product Datasheet
LIN28A Antibody
Catalog Number: 37118
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#: Q9H9Z2
NCBI Gene ID: 79727
Gene Accssion: NP_078950
- Form of Antibody:
- Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
- Immunogen:
- Synthetic peptide corresponding to residues near the N terminal of human lin-28 homolog A (C. elegans)
- appl_detail:
- Immunohistochemistry: 1:25-1:100
- other_names:
- CSDD1; LIN28; LIN-28; ZCCHC1; lin-28A
- Purification:
- Antigen affinity purification.
- Specificity:
- The antibody detects endogenous levels of total LIN28A protein.
- Background:
- LIN-28 is a highly conserved, RNA-binding, cytoplasmic protein. It consists of a cold shock domain and retroviral-type (CCHC) zinc finger motifs that were first identified in Caenorhabditis elegans. LIN-28 controls the timing of events during embryonic development and is readily expressed in embryos, embryonic stem cells and embryonal carcinoma cells. The presence of LIN-28 persists in some adult tissues including cardiac and skeletal muscle. In differentiating myoblasts, LIN-28 increases protein synthesis efficiency and binds to the growth and differentiation factor IGF-II.
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