Product Datasheet
ANAPC4 Antibody
Catalog Number: 37110
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#: Q9UJX5
NCBI Gene ID: 29945
Gene Accssion: NP_037499
- Form of Antibody:
- Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
- Immunogen:
- Synthetic peptide corresponding to a region derived from internal residues of human anaphase promoting complex subunit 4
- appl_detail:
- Western blotting: 1:200-1:1000
Immunohistochemistry: 1:50-1:200
- Purification:
- Antigen affinity purification.
- Specificity:
- The antibody detects endogenous levels of total ANAPC4 protein.
- Background:
- A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans.?
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