Product Datasheet
ATP1A1 Antibody
Catalog Number: 36978
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#: P05023
NCBI Gene ID: 476
Gene Accssion: NP_000692
- Form of Antibody:
- Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
- Immunogen:
- Synthetic peptide corresponding to a region derived from internal residues of human ATPase, Na+/K+ transporting, alpha 1 polypeptide
- appl_detail:
- Immunohistochemistry: 1:25-1:100
- other_names:
- AT1A1; ATP1A1; alpha 1 polypeptide; MGC3285;
- Purification:
- Antigen affinity purification.
- Specificity:
- The antibody detects endogenous levels of total ATP1A1 protein.
- Background:
- The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene.
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