Product Datasheet  
ADRBK1 Antibody  
Catalog Number: 36916  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P25098
    NCBI Gene ID: 156
    Gene Accssion: NP_001610
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthetic peptide corresponding to a region derived from internal residues of human adrenergic, beta, receptor kinase 1
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Immunohistochemistry: 1:100-1:300
  • other_names：  
  • GRK2; BARK1; BETA-ARK1
  • Purification：  
  • Antigen affinity purification.
  • Specificity：  
  • The antibody detects endogenous levels of total ADRBK1 protein.
  • Applications：  
  • IHC
  • Background：  
  • The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.



 
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