Product Datasheet  
CDKN1C Antibody  
Catalog Number: 36788  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P49918
    NCBI Gene ID: 1028
    Gene Accssion: NP_000067
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthetic peptide corresponding to residues near the N terminal of human cyclin-dependent kinase inhibitor 1C (p57, Kip2)
  • reactivity：  
  • Hu
  • appl_detail：  
  • Immunohistochemistry: 1:25-1:100
  • other_names：  
  • BWS; WBS; p57; BWCR; KIP2; IMAGE
  • Purification：  
  • Antigen affinity purification.
  • Specificity：  
  • The antibody detects endogenous levels of total CDKN1C protein.
  • Applications：  
  • IHC
  • Background：  
  • This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.



 
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