Product Datasheet
MT3 Antibody
Catalog Number: 36609
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#: P25713
NCBI Gene ID: 4504
Gene Accssion: BC013081
- Form of Antibody:
- Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
- Immunogen:
- Full length fusion protein
- appl_detail:
- Immunohistochemistry: 1:50-1:200
- other_names:
- GIF; GIFB; GRIF; ZnMT3
- Purification:
- Antigen affinity purification.
- Specificity:
- The antibody detects endogenous levels of total MT3 protein.
- Background:
- Metallothionein (MT) is a sulfhydryl- and cysteine-rich protein found in micro-organisms, plants and all invertebrate and vertebrate animals. Metallothioneins are a group of ubiquitous low-molecular-weight proteins that have functional roles in cell growth, repair and differentiation. Metallothionein are implicated primarily in metal ion detoxification as they are essential for the protection of cells against the toxicity of cadmium, mercury and copper. Metallothioneins are known to be broadly expressed in heart, liver, kidney, breast and testis tissue. Metallothionein 3, also known as MT-3 or GIFB (growth inhibitory factor), is a 68 amino acid protein that belongs to the type 1 family and Metallothionein superfamily. While highly expressed in astrocytes of the normal human brain, Metallothionein 3 expression is reduced in the brains of patients with Alzheimer disease.
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