Product Datasheet
KARS Antibody
Catalog Number: 36565
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#: Q15046
NCBI Gene ID: 3735
Gene Accssion: BC004132
- Form of Antibody:
- Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
- Immunogen:
- Fusion protein corresponding to residues near the C terminal of human lysyl-tRNA synthetase
- appl_detail:
- Western blotting: 1:500-1:2000
Immunohistochemistry: 1:100-1:300
- other_names:
- KRS; KARS1; KARS2; CMTRIB; DFNB89
- Purification:
- Antigen affinity purification.
- Specificity:
- The antibody detects endogenous levels of total KARS protein.
- Background:
- Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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