Product Datasheet
ITGAE Antibody
Catalog Number: 36557
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#: P38570
NCBI Gene ID: 3682
Gene Accssion: BC113436
- Form of Antibody:
- Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
- Immunogen:
- Fusion protein corresponding to a region derived from internal residues of human integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
- other_names:
- CD103; HUMINAE
- Purification:
- Antigen affinity purification.
- Specificity:
- The antibody detects endogenous levels of total ITGAE protein.
- Background:
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation.
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