Product Datasheet
GALT Antibody
Catalog Number: 36494
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#: P07902
NCBI Gene ID: 2592
Gene Accssion: NP_000146
- Form of Antibody:
- Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
- Immunogen:
- Fusion protein corresponding to a region derived from internal residues of human galactose-1-phosphate uridylyltransferase
- appl_detail:
- Western blotting: 1:500-1:2000
Immunohistochemistry: 1:50-1:200
- other_names:
- Gal-1-P uridylyltransferase;galactose-1-phosphate uridyl transferase
- Purification:
- Antigen affinity purification.
- Specificity:
- The antibody detects endogenous levels of total GALT protein.
- Background:
- Galactose-1-phosphate uridyl transferase (GALT) catalyzes the second step of the Leloir pathway of galactose metabolism, namely the conversion of UDP-glucose + galactose-1-phosphate to glucose-1-phosphate + UDP-galactose. The absence of this enzyme results in classic galactosemia in humans and can be fatal in the newborn period if lactose is not removed from the diet. The pathophysiology of galactosemia has not been clearly defined. Two transcript variants encoding different isoforms have been found for this gene.
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