Product Datasheet
DIRAS3 Antibody
Catalog Number: 36135
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#: O95661
NCBI Gene ID: 9077
Gene Accssion: BC005362
- Form of Antibody:
- Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
- Immunogen:
- Fusion protein corresponding to residues near the N terminal of human DIRAS family, GTP-binding RAS-like 3
- appl_detail:
- Immunohistochemistry: 1:15-1:50
- Purification:
- Antigen affinity purification.
- Specificity:
- The antibody detects endogenous levels of total DIRAS3 protein.
- Background:
- This gene is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers. It is an imprinted gene, with monoallelic expression of the paternal allele, which is associated with growth suppression. Thus, this gene appears to be a putative tumor suppressor gene whose function is abrogated in ovarian and breast cancers.
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