Product Datasheet
NOL3 Antibody
Catalog Number: 36121
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#: O60936
NCBI Gene ID: 8996
Gene Accssion: BC012798
- Form of Antibody:
- Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
- Immunogen:
- Full length fusion protein
- appl_detail:
- Immunohistochemistry: 1:50-1:200
- other_names:
- ARC; FCM; MYP; NOP; NOP30
- Purification:
- Antigen affinity purification.
- Specificity:
- The antibody detects endogenous levels of total NOL3 protein.
- Background:
- This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for this gene. Arc has been shown to localize to the cytoskeleton of neuronal cells and appears to colocalize with F-Actin, although it may associate with an Actin-associated protein rather than directly with F-Actin. It has been shown that cocaine-stimulated neuronal activity results in increased Arc mRNA levels in striatum.
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