Product Datasheet
MAP4 Antibody
Catalog Number: 35949
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#: P27816
NCBI Gene ID: 4134
Gene Accssion: BC008715
- Form of Antibody:
- Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
- Immunogen:
- Fusion protein corresponding to residues near the N terminal of human microtubule-associated protein 4
- appl_detail:
- Immunohistochemistry: 1:15-1:50
- other_names:
- DKFZp779A1753;MGC8617;Microtubule-associated protein 4
- Purification:
- Antigen affinity purification.
- Specificity:
- The antibody detects endogenous levels of total MAP4 protein.
- Background:
- The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene.
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