Product Datasheet  
DDB1 Antibody  
Catalog Number: 31182  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q9NRI5
    Gene ID:27185
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Synthetic peptide corresponding to a region derived from 1125-1140 amino acids of Human DNA damage-binding protein 1
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Predicted MW: 127kd
    ELISA: 1:500-1:5000
    Western blotting: 1:200-1:500
    Immunohistochemistry: 1:25-1:100
  • other_names：  
  • DNA damage-binding protein 1, XPE, DDBA, XAP1, XPCE, XPE-BF, UV-DDB1
  • Purification：  
  • Specificity：  
  • The antibody detects endogenous level of total DDB1 protein.
  • Applications：  
  • ELISA WB IHC
  • Background：  
  • The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.



 
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